Mechanism of Action of Phentermine
Phentermine is used in combination with diet and exercise to help you lose weight.
It works by decreasing your appetite.
Phentermine, like many other prescription drugs, works with neurotransmitters in the
brain. It is a centrally-acting stimulant and is a constitutional isomer of methamphetamine. It
stimulates neuron bundles to release a particular group of neurotransmitters known as catecholamines;
these include dopamine, epinephrine (also known as adrenaline), and norephinephrine (noradrenaline).
The anorectic activity seen with these compounds is thus likely due to their effect on the central
nervous system, which is consistent with current knowledge about the central nervous system and feeding
behavior. This is the same mechanism of action as other stimulant appetite suppressants such as
diethylpropion and phendimetrazine. The neurotransmitters signal a fight-or-flight response in the body
which in turn, puts a halt to the hunger signal. As a result, it causes a loss in appetite because the
brain does not receive the hunger message.
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